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Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
Vancomycin AUC and trough concentrations should be less than 800 μg × h/mL over 24 hours and 15 μg/mL, respectively, to minimize acute kidney injury (evidence quality: A-II). All the recommendations for pediatrics are new for the updated guideline.
20 gru 2014 · The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC).
Studies have shown that when serum vancomycin levels are maintained above 10 mcg/mL, the emergence of vancomycin intermediate-resistant S. aureus and vancomycin-resistant S. aureus are less likely to develop. 2 Consensus guidelines recommend a target trough concentration of 15 to 20 mcg/mL for clinical success in severe infections. 2 To reach ...
Vancocin®. Special Instructions. Peak levels should be ordered using Test No. 070327. Trough levels should be ordered using Test No. 070328. Please label tubes appropriately as “peak” and “trough.” Expected Turnaround Time. Within 1 day.
Hidayat et al.53 evaluated the use of high-dosage vancomycin intended to achieve un-bound trough serum vancomycin concentrations of at least four times the MIC in patients with MRSA infections. Of the. 95 patients evaluated with MRSA pneumonia or bacteremia, or both, 51 (54%) had vancomycin MIC values of 1.5 or 2 mg/L.
The 2020 vancomycin therapeutic guidelines recommends a move away from monitoring vancomycin trough levels to targeting an AUC 24:MIC (24-hour area under the curve (AUC) to minimum inhibitory concentration ratio). Dosing vancomycin using trough-only monitoring is no longer recommended.
