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Studies have shown that when serum vancomycin levels are maintained above 10 mcg/mL, the emergence of vancomycin intermediate-resistant S. aureus and vancomycin-resistant S. aureus are less likely to develop. 2 Consensus guidelines recommend a target trough concentration of 15 to 20 mcg/mL for clinical success in severe infections. 2 To reach ...
Two drug levels available (peak and trough): This is the most accurate method of calculating a patient-specific CL vanco and Vd; however, it requires two drug levels to be drawn. These patient-specific pharmacokinetic values can be calculated using the Sawchuk-Zaske method .
2 sie 2024 · Vancomycin is a glycopeptide antibiotic administered intravenously for treatment of patients with suspected or proven invasive gram-positive infections, including methicillin-resistant Staphylococcus aureus (MRSA).
Learn how to dose vancomycin based on area under the curve (AUC) and minimum inhibitory concentration (MIC) for serious MRSA infections. Find out how to use Bayesian dosing software and whether to use a loading dose.
Most CPGs recommended higher trough concentrations in patients with bacterial infections, infective endocarditis, osteomyelitis, meningitis and hospital-acquired pneumonia, but no CPG recommend trough concentrations greater than 20 µg/mL.
Peak versus trough concentrations Optimal trough concentration (see also Optimal trough concentration— complicated infections) Minimum serum vancomycin trough concentrations should always be maintained above 10 mg/L to avoid development of resistance. For a pathogen with an MIC of 1 mg/L, the minimum trough
Routine monitoring of vancomycin peak and trough concentrations in all adult patients receiving vancomycin therapy is not recommended unless therapy is longer than 5 days. Measurement of a single trough concentration at steady state is recommended for the following patients:
