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18 sty 2017 · The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can exert a tumour-suppressive effect through the proliferation...
- Targeting telomerase for cancer therapy | Oncogene - Nature
Telomere maintenance via telomerase reactivation is a nearly...
- Targeting telomeres: advances in telomere maintenance ... - Nature
Cancer cells establish replicative immortality by activating...
- Targeting telomerase for cancer therapy | Oncogene - Nature
20 cze 2016 · Telomeres, repetitive (TTAGGG) DNA–protein complexes at the ends of chromosomes, are crucial for the survival of cancer cells. They are maintained by an enzyme called telomerase in the vast majority of tumors.
30 lip 2020 · Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immortality. In contrast, telomerase activity is silenced in most adult...
Background. Although telomerase has potential for age-related disease intervention, the overexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against se in anti-aging telomerase therapeutics. While multiple reviews document the canonical function of telomerase for maintenance of telomeres, as well as an ...
5 sie 2024 · While many studies have examined telomere length (TL) and telomerase activity as prognostic biomarkers in human cancer, this review focuses on potential interactions between inflammation and telomere biology in cancer development.
5 lip 2022 · Cancer cells establish replicative immortality by activating a telomere-maintenance mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) pathway.
5 lut 2022 · Additionally, telomerase exhibits telomere-independent regulation of cancer cell growth by participating directly in cellular metabolism, signal transduction, and the regulation of gene expression in ways that are critical for tumorigenesis.
