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  1. Mandatory smallpox vaccination came into effect in Britain and parts of the United States of America in the 1840s and 1850s, as well as in other parts of the world, leading to the establishment of the smallpox vaccination certificates required for travel.

  2. From 1796 to the 1880s, the vaccine was transmitted from one person to another through arm-to-arm vaccination. Smallpox vaccine was successfully maintained in cattle starting in the 1840s, and calf lymph vaccine became the leading smallpox vaccine in the 1880s.

  3. The New World of the Western Hemisphere was devastated by the 1775–1782 North American smallpox epidemic. Estimates based on remnant settlements say at least 130,000 people were estimated to have died in the epidemic that started in 1775.

  4. The Founders argued that smallpox vaccination was the greatest discovery in modern medicine and they were likely correct that it helped to usher in the ... the great smallpox epidemic of 1775–82. New York: Hill and Wang; 2001. ... Riedel S. Edward Jenner and the history of smallpox and vaccination. Poc (Bayl Univ Med Cent). 2005;18(1):21–25

  5. Traditional medical history used to present a continuity from inoculation to Jenner’s vaccine in 1798 and subsequently to the national vaccination programmes of the nineteenth and twentieth centuries, ending in total triumph with the global eradication of smallpox in the 1980s. 1 The new medical history from the 1970s onwards has done much to ...

  6. Smallpox used to kill millions. But a chance discovery led to the first vaccine, and a transformation in human health.

  7. 31 mar 2017 · In 1798, Edward Jenner realized that cowpox, a harmless relative of smallpox, offered protection against smallpox and developed the first vaccination. In 1800 when Boston physician Benjamin Waterhouse introduced the cowpox vaccine to America, the success of Washington’s inoculation campaign of 1777 encouraged Americans to accept Jenner’s ...

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