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10 maj 2023 · This study aimed to improve the understanding of the prognostic value of tumor mitotic rate (TMR) in cutaneous melanoma and assessed its significance as a predictor for overall, melanoma-specific, and recurrence-free survival.
One unit increase in mitotic rate was shown to be correlated with 0.8 mm increase in Breslow thickness of the tumor (r=+0.8, P<0.001). We also categorized mitotic activity into three different levels (0–1 mitosis/mm 2, 2–3 mitosis/mm 2, and >4 mitosis/mm 2).
14 sie 2023 · Mitosis occurs infinitely. The cells never die in cancer, as cancer cells can utilize telomerase to add many telomeric sections to the ends of DNA during DNA replication, allowing the cells to live much longer than other somatic cells. With this mechanism, cancer cells that usually die simply continue to divide.
1 sty 2023 · Defects in structure, number amplification, and faulty function of centrosomes correlate with poor prognosis in diverse cancers. This is due to mitotic defects that cause unbalanced chromosome segregation, which leads to elevated aneuploidy and CIN resulting in an adaptive advantage for cancer cells [154], [155], [156], [157]. This advantage ...
23 lut 2023 · The effect of ulceration and the presence of mitosis/mm 2 on melanoma-associated death were analyzed for all tumor stages. A Cox proportional hazards model was used to evaluate the relationship between TMR and survival. The relative prognostic value of mitotic rate and ulceration was examined.
11 sie 2020 · Mitotic rate has long been known to be an important prognostic factor for melanoma. Numerous studies have demonstrated an adverse impact on survival with increasing numbers of mitoses. 5-13 As a result, it is a natural candidate for inclusion into the AJCC staging system.
10 maj 2023 · The prognostic significance of primary cutaneous melanoma tumor mitotic rate (TMR) has been of worldwide clinical interest for decades. Is there a path forward to build on the contributions from the ...
