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5 wrz 2024 · Anti-Ro/SSA antibodies may be the only autoantibodies present in a subset of patients with antinuclear antibody (ANA)-negative SLE. Additionally, anti-Ro/SSA antibodies (with or without anti-La/SSB antibodies) identify pregnant women who are at increased risk of having a child with neonatal lupus (NL).
- References
Anti-Ro/SSA antibodies may be the only autoantibodies...
- Medline
Recombinant SS-A/Ro antigen produced in bacteria proved to...
- Robert H Shmerling, MD
The anti-Ro/SSA and anti-La/SSB antigen-antibody systems....
- Antibodies to Double-Stranded (ds)DNA, Sm, and U1 RNP
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- Antiribosomal P Protein Antibodies
Chindalore V, Neas B, Reichlin M. The association between...
- References
Anti-SSA/Ro autoantibodies are used in clinical settings as a diagnostic tool to identify patients with SLE and Sjögren's syndrome. In clinical tests for autoimmune disease, Anti-Ro antibodies are some of the most consistently and frequently detected among autoantibodies.
6 gru 2012 · Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).
26 mar 2018 · Anti-Ro (also called anti-SSa) and anti-La (also called anti-SSb) AAbs are often associated with SS but can also occur in SLE with a prevalence between 36 and 64% and between 8 and 33.6% for anti-Ro AAb and anti-La AAb, respectively (37, 38, 61, 75, 76).
Emerging evidence suggests an arrhythmogenic effect of Anti-Ro/SSA (anti-Ro) and anti-La/SSB (anti-La) antibodies in adults, potentially involving a subclinical intracardiac inflammatory process.
Anti-Ro/SSA are the most prevalent specificity among many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous LE (SCLE), neonatal lupus and primary biliary cirrhosis. In contrast, anti-La/SSB is more associated with Sjögren's syndrome (SS).
14 lip 2020 · What Exactly Do the Anti-Ro/SSA and Anti-La/SSB Antigen–Antibody Systems Represent? Anti-Ro/Sjögren’s-syndrome-related antigen A (SSA) autoantibodies are directed against autoantigens Ro52 and Ro60, represented by distinct cellular proteins of 52 and 60 kDa, respectively.
