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16 paź 2019 · The pathophysiology of lung cancer is very complex and incompletely understood. It is hypothesized that repeated exposure to carcinogens, such as cigarette smoke leads to dysplasia of lung epithelium. If the exposure continues, it leads to genetic mutations and affects protein synthesis. [12]
Pathogenesis of lung cancer. Sun S, et al. Nat Rev Cancer 2007;7:778-790. The major function of the lungs is respiratory exchange. Inhaled air and potentially dangerous substances are conducted to the alveoli through a network of bronchi and bronchioles.
15 maj 2024 · The pathogenesis and biological mechanisms of PMA exhibit significant differences from other lung cancer subtypes. The cellular and molecular mechanisms of PMA involve several key processes (Table 2). (1) Regulation of mucin production and secretion: excessive production and secretion of mucin is a hallmark of PMA.
19 paź 2022 · The pathologic features of the major lung malignancies will be reviewed here. Clinical features, diagnosis, and management of patients with the different lung malignancies are discussed in the appropriate topic reviews.
Abstract. This article reviews current concepts in pathologic classification of lung cancer based on the 2004 World Health Organization classification of lung tumors and the 2011 International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification of lung adenocarcinoma.
21 lip 2020 · Small-cell lung cancer (SCLC) is a highly malignant tumor derived from cells exhibiting neuroendocrine characteristics and accounts for 15% of lung cancer cases. Non-small-cell lung cancer (NSCLC), which accounts for the remaining 85% of cases, is further divided into three major pathologic subtypes: adenocarcinoma, squamous cell carcinoma, and ...
27 sty 2012 · Abstract. The majority of lung adenocarcinoma patients with epidermal growth factor receptor- (EGFR) mutated or EML4–ALK rearrangement-positive tumors are sensitive to tyrosine kinase...
