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24 lip 2018 · There are multiple levels of CNS involved in the transmission of pain. These include the spinal cord (supraspinal), the brainstem (midbrain, medulla oblongata and the pons), and the cortical regions (cerebral cortex), as shown in Figure 1.
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Pain has been considered as a concept of sensation that we...
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The pain-associated neurotransmitters releasing location,...
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Pain has been considered as a concept of sensation that we...
- PMC Free Article
Recent studies have shown that PGF 2α also plays a...
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Prostaglandins are lipid autacoids derived from arachidonic...
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10 wrz 2023 · There are many different types of pain, each arising through unique mechanisms. Types of pain include: sharp, prickling, thermal, or aching pain. The origin of pain can be somatic, visceral, thalamic, neuropathic, psychosomatic, referred, or illusionary. Pain can also be acute or chronic in nature.
We review many of the recent findings concerning mechanisms and pathways for pain and its modulation, emphasizing sensitization and the modulation of nociceptors and of dorsal horn nociceptive neurons.
1 lis 2021 · The genetic and epigenetic factors modulate neuroinflammation, which is involved in peripheral and central sensitization. Chronic pain, with a prevalence of 20–30 % is the major cause of human suffering worldwide. Perceived pain disability correlates highly with suffering, little with painfulness.
9 lut 2023 · The transmission of pain is linked to nociceptors, which are a specialized subset of sensory neurons that mediate pain and densely innervate peripheral tissues. Various subsets of nociceptors are further divided according to the type of stimuli (mechanical, chemical, thermal, or noxious) they respond to [1].
10 lis 2021 · Given the known differential expression of δ and μ receptors in the brain’s pain pathways (35, 36), these results suggested that distinct circuits (and molecules in these circuits) control different nocifensive behaviors during the hotplate pain experience.
Pain involves a complex interplay between messages sent from the periphery to the central nervous system and vice versa. Specific pathways play a vital role in carrying these messages, and modulating, or exacerbating their downstream effects.
