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18 paź 2023 · MEN type 4 (MEN4) is the most recently identified type of MEN. Although it shares a similar phenotype spectrum to MEN1, MEN4 is rare. The difference between MEN1 and MEN4 lies in the germline gene mutation: in MEN1, there is a mutation of the MEN1 gene; in MEN4, there is a mutation in the cyclin-dependent kinase inhibitor 1B gene ( CDKN1B ).
- NBK568728
MEN type 4 (MEN4) is a rare autosomal dominant endocrine...
- GeneReviews®
Multiple endocrine neoplasia type 4 (MEN4) is characterized...
- Endotext
Multiple Endocrine Neoplasia Type 4 (MEN4) (OMIM #610755)...
- NBK568728
21 wrz 2023 · Multiple endocrine neoplasia type 4 (MEN4) is characterized by the development of endocrine tumors, especially those involving the parathyroid and/or pituitary gland. Parathyroid adenomas and parathyroid hyperplasia manifest as hypercalcemia (primary hyperparathyroidism) as a result of the overproduction of parathyroid hormone.
18 paź 2023 · MEN type 4 (MEN4) is a rare autosomal dominant endocrine tumor syndrome. The most common tumors seen in this condition involve the parathyroid glands, anterior pituitary, and gastro-entero-pancreatic neuroendocrine tissues.
Mnoga gruczolakowatość wewnątrzwydzielnicza, gruczolakowatość wewnątrzwydzielnicza (ang. multiple endocrine neoplasia, MEN) może dotyczyć różnych narządów, obejmuje trzy zespoły określane jako MEN I, MEN IIa, MEN IIb, dziedziczone w sposób autosomalny dominujący.
28 lut 2022 · Multiple Endocrine Neoplasia Type 4 (MEN4) (OMIM #610755) was initially named MENX and was first described in rats (1 - 3). MEN4 is caused by germline mutations in CDKN1B (Cdkn1b in rats), a tumor suppression gene encoding for the protein p27Kip1 (commonly referred to as p27 or as KIP1).
MEN4 is a rare inherited cancer syndrome with parathyroid and pituitary tumors, possibly associated with other organ tumors. It is caused by mutations in the CDKN1B gene and has autosomal dominant inheritance.
26 sie 2023 · MEN4 is a multiglandular neoplasia syndrome caused by germline mutations in the CDKN1B gene, encoding the cell cycle regulator p27. It is clinically similar to MEN1 but with milder features and older onset, and involves parathyroid, pituitary and neuroendocrine tumors.
