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Glucose metabolism provides the fuel for physiological brain function through the generation of ATP, the foundation for neuronal and non-neuronal cellular maintenance, as well as the generation of neurotransmitters.
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Generation of energy in brain and three models for the fate...
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19 gru 2018 · Function–metabolism coupling is the basis for metabolic brain imaging using glucose analogs and for MRS assays of pathway fluxes. Metabolic rates are heterogeneous on the regional, cellular, and subcellular levels, with signaling activities requiring the largest amounts of ATP.
1 sty 2019 · Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, and structural components.
1 sty 2021 · Glucose homeostasis in the brain is regulated by various metabolic processes, including key regulatory enzymes in glycolysis, glucose-associated metabolic pathways, glucose-sensing neurons in the hypothalamus, and by endocrine hormones.
11 lut 2019 · The correspondence between cerebral glucose metabolism (indexing energy utilization) and synchronous fluctuations in blood oxygenation (indexing neuronal activity) is relevant for neuronal...
11 mar 2016 · The brain senses peripheral metabolic signals through hormones (insulin, leptin and so on) and nutrients (glucose, free fatty acids and so on) to regulate glucose metabolism.
Glucose enters cells through glucose transporters (GLUTs) and is phosphorylated by hexokinase (HK) to produce glucose-6-phosphate (glucose-6P). Glucose-6P can be processed through three main metabolic pathways.
