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7 sie 2023 · The genetic mutations that contribute to the transformation of healthy cells into cancerous cells have been the subject of extensive research. The molecular aberrations that lead to cancer...
- Mutational drivers of cancer cell migration and invasion
Genomic instability and mutations underlie the hallmarks of...
- A compendium of mutational cancer driver genes - Nature
This review describes frequent alterations to genes, and...
- Mutational drivers of cancer cell migration and invasion
18 lis 2020 · Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations determine cancer cell fate by affecting cell proliferation, apoptosis and immune response, and...
10 sie 2020 · This review describes frequent alterations to genes, and biochemical pathways driving cancer as well as a simple approach to identify recurrently mutated cancer driver genes across a cohort...
It typically takes more than one gene mutation for a cell to become a cancer cell. But when someone inherits an abnormal copy of a gene, their cells already start out with one mutation. This makes it easier (and quicker) for other mutations to happen, which can lead to a cell becoming a cancer cell.
17 kwi 2023 · Cancer driver mutations may affect cell-cycle control, leading to insensitivity to growth inhibitory signals and escape from immune surveillance. Therefore, driver mutations confer a selective advantage and are usually under positive selection in cancer.
20 sie 2020 · A systematic approach combining several of these signals could lead to a compendium of mutational cancer genes. In this Review, we present the Integrative OncoGenomics (IntOGen) pipeline, an implementation of such an approach to obtain the compendium of mutational cancer drivers.
We found that the aggregated impact of putative passengers provides significant predictive power—beyond common driver mutations—to distinguish cancer from non-cancer phenotypes, even after controlling for known mutational processes and background mutation rates.
