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The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had a fatality rate of around 30%, while variola minor’s mortality rate was about 1%.
This study reports the development of a real-time PCR minor groove binder (MGB)-Eclipse probe assay utilizing a sequence within the variola B9R/B10R gene complex that reliably differentiates V. major from V. minor by specific probe melting temperatures (T (m)s) and genotyping analysis.
22 mar 2019 · Smallpox is a contagious and sometimes fatal disease caused by two related viruses: variola major and variola minor. Variola major is the more common and severe form, with an overall historical fatality rate of about 30%.
There are at least 2 strains of smallpox virus: Variola major (classic smallpox), the more virulent strain. Variola minor (alastrim), the less virulent strain. Smallpox is transmitted from person to person by inhalation of respiratory droplets or, less efficiently, by direct contact.
21 cze 2016 · Smallpox has two main forms: variola major and variola minor. The two forms showed similar lesions. The disease followed a milder course in variola minor, which had a case fatality rate of less than 1 per cent. The fatality rate of variola major was around 30%.
The variola virus causes smallpox. There are two variants of variola: variola major and variola minor (or variola alastrim). Variola major caused most cases of smallpox and the most deaths.
The smallpox virus can exist only in people—not in animals. There are two main forms: The severe form (variola major) is the most common and is the one of concern. The other form (variola minor) is much less common and much less severe. Throughout history, smallpox has killed millions of people.
