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It is well known that chronic alcoholics are at high risk for being deficient in vitamin B1 (thiamine), which is known to put the patient at an increased risk for Wernicke-Korsakoff Syndrome, cerebellar degeneration, and cardiovascular dysfunction.
26 cze 2023 · Wernicke-Korsakoff syndrome is a common complication of a thiamine deficiency that is primarily seen with alcoholics. This syndrome was classically described as a clinical triad consisting of altered mental status (i.e., confusion or dementia), nystagmus (or ophthalmoplegia), and ataxia.
4 kwi 2022 · Wernicke-Korsakoff syndrome happens due to a lack of thiamine. This essential vitamin changes (converts) sugar into energy. When you have too little thiamine, your brain doesn’t have enough energy to work properly. The most common cause of thiamine deficiency is chronic alcohol use.
Two double-blind, parallel groups, randomized controlled trials (RCTs) were conducted to determine the optimal thiamine dose required for (1) the prevention of Wernicke's encephalopathy (WE), the acute phase of WKS, in asymptomatic but “at-risk” alcohol misuse patients (Study 1) and (2) the treatment of WE in symptomatic alcohol misuse patients ...
4 maj 2020 · Abstract. Thiamine is essential for the activity of several enzymes associated with energy metabolism in humans. Chronic alcohol use is associated with deficiency of thiamine along with other vitamins through several mechanisms.
1 mar 2020 · In the management of patients with alcohol dependence, physicians should have a high index of suspicion for thiamine-deficient states, especially Wernicke-Korsakoff syndrome. Given the potential benefit of preventing thiamine deficiency, oral thiamine supplementation is a consideration in the office management of alcohol use disorders and ...
12 kwi 2011 · MRI should be used to support the diagnosis of acute WE in patients both with and without alcoholism. Thiamine is indicated for the treatment of suspected or manifest WE, and should be ...
