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Vitamin K therapy improves hemostasis in Vitamin K deficient patients. It is often initiated pending test results, but maintenance of vitamin K is not indicated for patients having diagnoses of thrombocytopenia, hereditary factor deficiencies, or DIC.
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Vitamin K compounds are used in the treatment and prevention of haemorrhage associated with vitamin K deficiency and also as antagonists for anticoagulant poisoning (e.g. rodenticide toxicity and sweet clover poisoning).
Vitamin K is a fat-soluble vitamin essential for the post-translational processing of the prothrombin group of coagulation factors (Factors II, VII, IX, and X). Vitamin K deficiency causes excessive bleeding due to failure of normal fibrin clot formation.
Vitamin K therapy is often initiated even in asymptomatic animals. Vitamin K 1, 2.5–3 mg/kg SC, is recommended for initial treatment of coumarin toxicity, followed by 1.25–2.5 mg/kg, PO, twice daily for 4–6 days, followed by measurement of PT 48 hours later. For other longer-lasting anticoagulants, treatment should be continued for ...
1 mar 2018 · Safety of Vitamin K 1. The initial requirement of vitamin K 1 established for puppies is ≥ 10 μg/kg (4.5 mg/lb) IV and for adult dogs is < 5 μg/kg (2.3 μg/kg) IV. 40 These requirements were established by use of cholecystnephrostomy to reduce the ability to absorb vitamin K.
It may take 6–12 hours for vitamin K to take effect. Oral absorption in dogs is enhanced 4–5 times when administered with tinned food, particularly those with higher fat content. Prothrombin time is the preferred method for monitoring therapy.
Objective: To compare the efficacy of fresh frozen plasma (FFP) with cryopoor plasma (CPP) to treat vitamin K-dependent factor deficiency in a canine in vitro setting. Design: In vitro laboratory study. Setting: University veterinary medical teaching hospital.
