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16 cze 2021 · The discussion identifies the need for a systematic framework to probe feedback loops, unravel their versatile roles in biological organization, and understand the tradeoffs they induce for cellular function.
1 gru 2013 · We review examples of all of these and discuss what functions they perform. The study of eukaryotic cell cycle regulation over the last several decades has led to a remarkably detailed understanding of the complex regulatory system that drives this fundamental process.
In this article, control theory is discussed as an approach to dissect the control logic of complex pathways. One of the key issues is distinguishing between the terms control and regulation and how these concepts are applied to regulated enzymes such as phosphofructokinase.
15 wrz 2010 · In mammalian cells, several proteins that are not part of the core replication machinery promote the efficient restart of stalled replication forks, which suggests that fork restart pathways...
8 lis 2006 · In general, restart involves three steps: processing of the stalled fork to generate proper strand configurations; structure-specific recognition of the stalled fork by one of the restart...
30 lis 2017 · Replication restart requires recognition and remodeling of abandoned replication forks by DNA replication restart proteins followed by reloading of the replicative DNA helicase, which subsequently directs assembly of the remaining replisome subunits.
The feed-forward loop is subgraph 5, and the feedback loop is subgraph 9. Patterns with 3 nodes • 13 possible 3-node patterns • Turns out that only one of them, the feed-forward loop (FFL) is a network motif (i.e., it occurs unexpectedly often in a transcription network) • 8 possible FFL types (as there are 8
