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In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
2 sie 2024 · Learn how to optimize vancomycin therapy for invasive gram-positive infections, including MRSA, based on guidelines and literature review. Find out how to monitor vancomycin serum concentrations and adjust dosing based on kidney function and pathogen susceptibility.
Learn about vancomycin, an antibiotic drug used to treat serious infections by gram-positive bacteria. Find out the therapeutic range, how to monitor trough and peak levels, and the risks of nephrotoxicity and resistance.
22 lut 2023 · A comprehensive guide for vancomycin dosing based on pharmacodynamic targets, renal function, and indication. Includes loading dose, maintenance dose, monitoring, and discharge criteria for intermittent and continuous infusion.
Calculate vancomycin dosing regimen for adult patients using pharmacokinetic models, Bayesian modeling, and drug levels. Enter patient parameters, renal function, and doses of vancomycin given to patient to optimize trough and AUC/MIC.
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
24 mar 2023 · Obtaining vancomycin serum trough concentrations allows healthcare professionals to evaluate the efficacy of the vancomycin dosing regimen and clearance of the drug by the individual patient. The target therapeutic serum trough concentration varies depending on the indication and typically ranges between 10 mcg/mL to 20 mcg/mL.
