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In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
Trough monitoring (10–20 mg/L) has been traditionally used...
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
Trough monitoring (10–20 mg/L) has been traditionally used and may be less resource intensive in some settings, while providing reasonable ability to predict efficacy outcomes. The risk of nephrotoxicity has been demonstrated to incrementally increase with greater exposure (as measured by trough or AUC 24), even
15 paź 2024 · Vancomycin remains widely used for methicillin-resistant Staphylococcus aureus (MRSA) infections; however, treatment failure rates up to 50% have been reported. At the authors’ institution, monitoring of trough concentration is the standard of care for therapeutic drug monitoring of vancomycin.
Minimum serum vancomycin trough concentrations should always be maintained above 10 mg/L to avoid development of resistance. For a pathogen with an MIC of 1 mg/L, the minimum trough concentration would have to be at least 15 mg/L to generate the target AUC:MIC of 400. IIIB Therapeutic vancomycin drug monitoring, Optimal trough concentrations
1 kwi 2019 · Current consensus guidelines recommend measuring trough vancomycin concentrations during intermittent dosing as a surrogate for the AUC 24. Trough concentrations are a misleading surrogate for AUC 24 and a poor end-point in themselves.
1 sie 2009 · The article summarizes the consensus recommendations from expert panels on how to monitor and adjust vancomycin therapy for Staphylococcus aureus infections. It suggests trough serum concentrations of 15–20 mg/L as the target and provides evidence-based guidance on dosage, infusion, and resistance.
