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22 lut 2023 · Initial: A single level should be drawn within the first 24-48 hours after the first dose. An earlier initial level may be helpful in ensuring therapeutic concentrations in certain clinical scenarios (i.e. critically ill patients, patients with high or low BMI, etc.)
This vancomycin calculator uses pharmacokinetic population estimates, Bayesian modeling, and the Sawchuk-Zaske method to calculate a vancomycin dosing regimen for an adult patient. Vancomycin regimens can be calculated both empirically (without any prior doses) or using one or two vancomycin levels.
2 sie 2024 · Appropriate dosing and administration of vancomycin requires consideration of the pathogen and its susceptibility, type and severity of infection, patient weight, and kidney function . The optimal approach to vancomycin dosing and monitoring for invasive methicillin-resistant S. aureus (MRSA) infections is a subject of ongoing controversy and ...
Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) - Trough levels should be obtained within 30 minutes before the next scheduled dose.
Approach to vancomycin dosing for adults with normal kidney function*. Loading dose (for patients with known or suspected severe Staphylococcus aureus infection) ¶. Load 20 to 35 mg/kg (based on actual body weight, rounded to the nearest 250 mg increment; not to exceed 3000 mg).
Principles of vancomycin dosing: There are two main protocols used: AUC or trough. Specific AUC or trough goals will be dependent on the indication. Most indications -> AUC 400-600, trough 10-20**. Trough 15-20 ONLY in the following indications: CNS dosing/Meningitis.
In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
