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Abstract. Newly emerging technologies are rapidly changing conventional approaches to organ transplantation. In the modern era, the key challenges to transplantation include (1) how to best individualize and possibly eliminate the need for life-long immunosuppression and (2) how to expand the donor pool suitable for human transplantation.
13 lut 2019 · Abstract. Newly emerging technologies are rapidly changing conventional approaches to organ transplantation. In the modern era, the key challenges to transplantation include (1) how to best...
13 mar 2017 · Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies.
26 maj 2023 · As our understanding of transplant immunology and synthetic biology improves, we are able to manipulate biological devices (therapeutic antibodies, antibody derivatives, chimeric proteins, and so on) with the aim of fine-tuning the immune responses after SOT.
28 mar 2019 · Advances in organ and tissue preservation. For decades, organ cooling has been an essential part of organ and tissue transplantation. Low temperatures decrease metabolic rate by factor 1.5–3 per 10 °C, so cooling a donor organ to 4 °C reduces its metabolic rate to 10–12% of the baseline 11.
Cell transplantation (see Glossary) is a technique where cells obtained from a patient are harvested, expanded in culture, seeded onto an appropriate scaffold, and then transplanted to the defect site, and has the potential to revolutionize the way we think about personalized medicine [1–3].
21 paź 2024 · Transplant Rejection. The different types of grafts described above have varying risks for rejection (Table Section3.3.1 S e c t i o n 3.3. 1). Rejection occurs when the recipient’s immune system recognizes the donor tissue as foreign (non-self), triggering an immune response. The major histocompatibility complex markers MHC I and MHC II ...
