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23 wrz 2017 · In this study, skin diseases induced by genetic damages or autoimmune targeting of these enzymes will be discussed. TG1, TG3 and TG5 contribute to the cutaneous barrier and thus to the integrity and function of epidermis.
In autoimmune diseases, the epitope spreading is remarkable, while in some inherited pathologies, a unique compensation of the lost enzyme function is noted. Keywords: autosomal recessive ichthyosis; gluten-sensitive diseases; hair mutation; skin barrier defect; transglutaminases.
Autoimmunity to TG2, TG3 and TG6 may develop in a few of those genetically determined individuals who lost tolerance to gluten, and manifest as coeliac disease, dermatitis herpetiformis or gluten- dependent neurological symptoms, respectively. These gluten responder diseases commonly occur in combi-nation.
2 sty 2020 · Transglutaminase (EC 2.3.2.13, protein-glutamine gamma-glutamyltransferase, TGase) is a calcium-dependent enzyme, belonging to the class of transferases, which catalyzes the acyl-transfer between glutamine residues and a wide variety of primary amines (Ohtsuka et al. 2000).
1 lut 2003 · Overexpression of TGs is also implicated in skin disorders, in particular in the pathogenesis of psoriasis 115.
25 cze 2014 · Our group has identified a transglutaminase in the oomycete Phytophthora cinnamomi, which is able to induct defense responses and disease-like symptoms. In this mini-review, we report the achievements in this area in order to illustrate the importance and the versatility of transglutaminases.
1 lut 2020 · Transglutaminase 3 Promotes Skin Inflammation in Atopic Dermatitis by Activating Monocyte-Derived Dendritic Cells via DC-SIGN. Author links open overlay panel. Huichun Su 1 2 6. , Yang Luo 1 6. , Jing Sun 1. , Xiaochun Liu 1. , Shiqi Ling 1. , Beilei Xu 1. , Yu Zhang 1. , Jun Liu 3. , Wei Li 4. , Baoxi Wang 5. , Xu Yao 1. Show more. Add to Mendeley
