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In this study, skin diseases induced by genetic damages or autoimmune targeting of these enzymes will be discussed. TG1, TG3 and TG5 contribute to the cutaneous barrier and thus to the integrity and function of epidermis.
Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.
1 wrz 2005 · This reaction requires transglutaminase (TGase), which is a calcium-dependent enzyme catalyzing an intermolecular isopeptide bond formation between proteins. Among the nine TGases that have been identified in humans, TGases 1, 3, and 5 are known to participate in CE formation.
Transglutaminases. Skin functions as a stable, physical and chemical barrier from environmental influences. The cornified cell envelope (CE) is a critical structure for barrier function at the outermost layer of the skin epidermis.
25 wrz 2024 · Among the eight transglutaminase family members in mammals, transglutaminase 1 (TG1) plays a crucial role in skin barrier formation via crosslinking and insolubilizing proteins in keratinocytes. Despite this established function in skin, novel functions have begun merging in normal tissue homeostasis as well as in pathologies.
6 gru 2013 · TGs significantly contribute to the normal skin barrier formation, protecting the skin from exogenous damages by supporting wound healing and from contact allergen and microbial invasion by contributing to stratum corneum and CE formation. The human skin expresses TGs (Table1).
25 cze 2014 · Our group has identified a transglutaminase in the oomycete Phytophthora cinnamomi, which is able to induct defense responses and disease-like symptoms. In this mini-review, we report the achievements in this area in order to illustrate the importance and the versatility of transglutaminases.
