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  1. Among the major metabolites ( 9-THC,11-OH-THC, and THCCOOH), THCCOOH is the primary glucuronide conjugate in urine, while 11-OH-THC is the predominant form in feces (51, 69). Since 9 -THC is extremely soluble in lipids, it results in tubular re-absorption, leading to low renal excretion of unchanged drug.

  2. 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC) which is formed in the body after cannabis is consumed.

  3. 30 lis 2020 · Metabolism of cannabis is determined by the route of consumption. When inhaled, THC and its metabolites enter the bloodstream rapidly via the lungs; they achieve peak levels within 6 to 10 minutes and reach the brain and various organs. The bioavailability of inhaled THC is 10% to 35%.

  4. 11-Nor-9-karboksy-THC (11-nor-9-karboksy-Δ 9-tetrahydrokannabinol, 11-COOH-THC) – organiczny związek chemiczny z grupy kannabinoidów, drugi główny metabolit THC wytwarzany w organizmie po spożyciu konopi.

  5. 16 maj 2019 · This study characterized the urinary excretion profile of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH), the primary analytical outcome for detection of cannabis use, among infrequent cannabis users following controlled administration of both smoked and vaporized cannabis.

  6. 26 gru 2019 · When 11-OH-THC is oxidized by the same family of enzymes, it produces THC-COOH, an inactive metabolite which is one of the main end products of cannabis use. Usually by 30-45 minutes after smoking, THC-COOH concentrations have gradually increased and are found in higher levels than THC concentrations.

  7. 22 wrz 2023 · The majority of cases in Group A were positive for HHC-COOH, which is highly suggestive of in vivo generation of HHC-COOH from Δ 9-THC. The known metabolite THC-COOH was detected in 92% of the cases in Group A. The median concentrations of THC-COOH and 9 R-HHC-COOH were 21 ng/mL and 1.4 ng/mL

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