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3 kwi 2017 · Results obtained in mouse models with telomerase gene therapy as a treatment for aging-associated diseases and telomere syndromes, as well as shelterin chemical inhibition as anticancer therapy treatment, constitute promising opportunities for further clinical development.
Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy. Keywords: AAV9, aging, gene therapy, health span, TERT.
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
15 maj 2012 · Promoting healthspan in mice using a telomerase gene therapy. Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.
17 paź 2019 · Critically short telomeres in humans and mice can lead to premature aging and shorter lifespans by limiting the ability of stem cells to regenerate tissues 11,12,27.
At present, there are several reliable methods to investigate telomere dysfunction based on the activation and accumulation of DDR proteins at telomeres. tDDR can be evaluated in homogenized populations of cells or tissues using methods such as chromatin immunoprecipitation, or at single-cell resolution using immuno-FISH, which allows the ...
30 sty 2018 · We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres. AAV9 preferentially targets regenerative alveolar type II cells (ATII).
