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Treatment of 1- and 2-year old mice with an adeno associated virus (AAV) of wide tropism expressing mouse TERT had remarkable beneficial effects on health and fitness, including insulin sensitivity, osteoporosis, neuromuscular coordination and several molecular biomarkers of aging.
3 kwi 2017 · Results obtained in mouse models with telomerase gene therapy as a treatment for aging-associated diseases and telomere syndromes, as well as shelterin chemical inhibition as anticancer therapy treatment, constitute promising opportunities for further clinical development.
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
In mice, reactivation of endogenous telomerase reverses premature aging in mice with telomere dysfunction (Jaskelioff et al., 2011). Both killifish ( Harel et al., 2015 ) and zebrafish ( Carneiro et al., 2016 ) serve as models for telomere biology studies; their telomere length is similar to that of humans, while their telomere dysfunction ...
In the context of telomere biology, dysfunctional telomeres induce the accumulation of telomeric dilncRNA and DDRNA (cumulatively referred here as tncRNA). tncRNA targeting with ASOs (tASOs) selectively inhibited DDR at telomeres, as demonstrated in cultured cells and in mice, where they also reduced markers of cellular senescence and apoptosis ...
15 maj 2012 · Partial or complete loss of telomerase function dramatically accelerates aging in mice and promotes aging associated disorders in humans. Therefore, the presence of active telomerase in stem cells, and potentially in other cells, is vital for longevity and good health.
14 lip 2015 · Povedano et al. show that persistent telomeric damage induced by telomere dysfunction (either by shelterin disruption or by telomerase deficiency) triggers pulmonary fibrosis in mice. These mouse models are instrumental for the development of new therapeutic strategies to treat pulmonary fibrosis associated with telomere dysfunction.
