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24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative...
- Telomerase reactivation reverses tissue degeneration in aged telomerase ...
Ronald DePinho and colleagues now show that reactivation of...
- Telomerase reactivation reverses tissue degeneration in aged telomerase ...
28 lis 2010 · Ronald DePinho and colleagues now show that reactivation of endogenous telomerase in mice extends telomeres, reduces DNA damage signalling, allows resumption of proliferation in quiescent...
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
3 kwi 2017 · Results obtained in mouse models with telomerase gene therapy as a treatment for aging-associated diseases and telomere syndromes, as well as shelterin chemical inhibition as anticancer therapy treatment, constitute promising opportunities for further clinical development.
16 wrz 2020 · Telomere dysfunction can arise by loss of telomeric DNA repeats or loss of protection by the telomeric protein complex, that in turn elicit a DNA damage response, and loss of cell proliferation leading to senescence or apoptosis (d'Adda di Fagagna et al, 2003).
15 maj 2012 · Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging.
30 sty 2018 · Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.
