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30 sty 2018 · Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres.
14 lip 2015 · Trf1 Deletion in the Lung Induces Pulmonary Fibrosis and Decreases Mouse Survival. (A) Representative CT images of Trf1+/+ and affected Trf1Δ/Δ lungs. (B) Percentage of mice of both genders or only males with an abnormal CT pattern at week 9 after the beginning of TMX treatment.
24 cze 2014 · Abstract. Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the...
30 sty 2018 · We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres. AAV9 preferentially targets regenerative alveolar type II cells (ATII).
14 lip 2015 · telomeric damage induced by telomere dysfunction(eitherbyshelterindisruption or by telomerase deficiency) triggers pulmonary fibrosis in mice. These mouse models are instrumental for the development of new therapeutic strategies to treat pulmonary fibrosis associated with telomere dysfunction. Povedano et al., 2015, Cell Reports 12, 286–299
17 paź 2019 · We found that hyper-long telomere mice showed a reduction of almost 50% in the number of mice that developed tumors compared to the normal telomere length control mice, although this...
1 wrz 2001 · Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age‐related diseases produced by critical telomere shortening. However, it is not known whether or not short telomeres are irreversibly damaged.
