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24 cze 2014 · Senescent cells harbouring dysfunctional telomeres, which are recognized by persistent telomere-associated DNA damage foci (TAF), accumulate even in tissues of ageing mice with long telomeres...
15 maj 2012 · Treatment of 1‐ and 2‐year old mice with an adeno associated virus (AAV) of wide tropism expressing mouse TERT had remarkable beneficial effects on health and fitness, including insulin sensitivity, osteoporosis, neuromuscular coordination and several molecular biomarkers of aging.
19 paź 2022 · Telomere restoration therapy extends the lifespan of aged mice by 20%. Our telomeres shorten as we age, causing our DNA repair systems to malfunction. In response, affected cells convert to a senescent state, secreting molecules known as the senescence-associated secretory phenotype (SASP).
14 lut 2022 · Mouse studies indicate that telomere dysfunction can recapitulate IPF features. Mice with short telomeres induced by knockout of telomerase components show TAFs, inflammation and fibrosis...
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
14 lip 2015 · Here, we generate two independent mouse models that develop IPF owing to either critically short telomeres (telomerase-deficient mice) or severe telomere dysfunction in the absence of telomere shortening (mice with Trf1 deletion in type II alveolar cells). We show that both mouse models develop pulmonary fibrosis through induction of telomere ...
3 lip 2024 · Telomeres, posted at the edges of chromosomes, protect DNA from damage. The telomerase enzyme helps maintain the length and integrity of telomeres and acts as an aging regulator. Researchers have now found a new small molecule that restores telomerase levels and reverses hallmarks of aging in elderly mice.
