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24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative...
17 paź 2019 · We found that hyper-long telomere mice showed a reduction of almost 50% in the number of mice that developed tumors compared to the normal telomere length control mice, although this...
19 paź 2022 · Telomere restoration therapy extends the lifespan of aged mice by 20%. Our telomeres shorten as we age, causing our DNA repair systems to malfunction. In response, affected cells convert to a senescent state, secreting molecules known as the senescence-associated secretory phenotype (SASP).
14 lip 2015 · Here, we generate two independent mouse models that develop IPF owing to either critically short telomeres (telomerase-deficient mice) or severe telomere dysfunction in the absence of telomere shortening (mice with Trf1 deletion in type II alveolar cells). We show that both mouse models develop pulmonary fibrosis through induction of telomere ...
1 lis 2023 · Compared with mice with long telomere reserve, telomerase knockout mice showed reduced neurogenesis in the dentate gyrus, loss of neurons in the hippocampus and frontal cortex, and related to short-term memory deficits.
30 sty 2018 · We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres. AAV9 preferentially targets regenerative alveolar type II cells (ATII).
3 lip 2024 · The telomerase enzyme helps maintain the length and integrity of telomeres and acts as an aging regulator. Researchers have now found a new small molecule that restores telomerase levels and ...
