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In this review, we describe the changes in telomerase and telomere length (TEL) during development, their role in carcinogenesis processes, and the consequences of reduced telomerase activity. More specifically, the connection of TEL in peripheral blood cells with the development of aging-associated diseases is discussed.
- Telomerase gene therapy: a novel approach to combat aging
Promoting healthspan in mice using a telomerase gene...
- Therapeutic Targeting of Telomerase - PMC - National Center for ...
Telomerase-directed gene therapy. The promoters for...
- Telomerase gene therapy in adult and old mice delays aging and ...
Together, these results constitute a proof-of-principle of a...
- Telomerase gene therapy: a novel approach to combat aging
14 lut 2022 · Here, we summarized age-related conditions that bear an often-unappreciated underlying cause in telomere dysfunction, either in the form of telomere shortening or telomere DNA damage.
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
15 maj 2012 · Promoting healthspan in mice using a telomerase gene therapy. Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.
21 lip 2016 · Telomerase-directed gene therapy. The promoters for telomerase in cancer cells are targets for a tumor specific gene therapy that selectively kills cancer cells and leaves normal cells unharmed by expressing high concentrations of a therapeutic protein only in cancer cells.
Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy.
In summary, telomerase and its regulation of telomere length is both an important target for cancer therapy and for the treatment of age-related disease. The telomerase gene will likely have many important applications in the future of medicine and cellular engineering.
