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14 maj 2024 · If the first TB skin test result is negative, a second TB skin test should be done 1 to 3 weeks later. If the second TB skin test result is positive, it is probably a boosted reaction. Based on this second test result, the person should be classified as previously infected.
20 paź 2020 · Diagnosis and treatment of TB infection (TBI) is a pillar of the WHO End TB strategy to achieve a global reduction in TB incidence by 2035. Accurate diagnostic tests are needed to better identify individuals who would benefit from preventive treatment.
23 kwi 2023 · Tuberculosis (TB) is a potentially fatal bacterial infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis). It is a highly contagious droplet infection that primarily affects the lungs. However, it can affect numerous organ systems.
You may need a second skin test 8 to 10 weeks after the last time you spent time with someone with active TB disease. This is because it can take several weeks after infection for your immune system to react to the TB skin test. If your reaction to the second test is negative, you likely do not have inactive TB or active TB disease.
The diagnostic tests in current use for identification of TB infection are the tuberculin skin test (TST) and interferon-gamma release assay (IGRA). The safety of TST, an in-vivo test, is well established and associated with only uncommon adverse reactions.
When given a TST years after infection, these persons may have an initial negative reaction. However, the TST may stimulate the immune system, causing a positive or boosted reaction to subsequent tests. Giving a second TST after an initial negative TST reaction is called two-step testing.
The skin test reaction should be read between 48 and 72 hours after administration. A patient who does not return within 72 hours will need to be rescheduled for another skin test. The reaction should be measured in millimeters of the induration (palpable, raised, hardened area or swelling).
