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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
4 sty 2022 · RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics...
19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
19 lis 2018 · We tested the performance of this miR-21-responsive RNA device by co-transfecting it with miR-21 mimic (chemically modified RNA that mimics endogenous miRNA) into 293FT cells.
2 lis 2021 · DNA encodes bioparts, bioparts are combined to make biological devices, and devices are built into biological systems. Synthetic biology is working towards a ‘plug-and-play’ concept, in which off-the-shelf bioparts will be able to be loaded and run in finely characterised chasses.
