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4 sty 2022 · RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics...
Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional modifications (part A ), circular RNA (circRNA) mechanisms (part B) and novel uses of RNA scaffolds (part C ).
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
19 lis 2018 · Thus, we aimed to design synthetic RNA-delivered logic circuits that function in mammalian cells by improving the performance of miRNA- and protein-responsive modRNAs.
23 wrz 2019 · Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in...
11 lip 2019 · From expanding the number of genetically encoded amino acids to creating new genetic tools in diverse microbes, these articles are each exemplars of the sophisticated synthetic biology approaches that produce cells with new capabilities, enabling the production of designer proteins and RNAs.
19 maj 2017 · The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information. Additionally, endogenous protein-responsive RNA devices can be used to measure the protein expression level in living cells.
