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4 sty 2022 · RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics...
4 sty 2022 · Leveraging the dependence of the CRISPR system on a guide RNA (gRNA), researchers designed a control system that incorporates small molecule-responsive aptamers into the 3′ region of the gRNA to...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
11 lip 2019 · This special issue of Genes on “Synthetic DNA and RNA Programming” features 12 original research articles and reviews that highlight novel aspects of basic molecular and cellular biology, uncovered by the application and development of synthetic biology-driven approaches.
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
20 lut 2012 · An abstraction hierarchy that dissects the engineering process into several design levels - DNA, parts, devices, and systems - provides synthetic biologists with a means to manage complexity and distribute tasks.
19 lis 2018 · In this study, we construct a set of RNA-based logic circuits with RBPs that detect multiple miRNA inputs and regulate the output protein expression (Fig. 1a). We create five logic gates...
