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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional modifications (part A ), circular RNA (circRNA) mechanisms (part B) and novel uses of RNA scaffolds (part C ).
19 maj 2017 · The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information. Additionally, endogenous protein-responsive RNA devices can be used to measure the protein expression level in living cells.
19 lis 2018 · Here we show synthetic mRNA-delivered circuits with RNA-binding proteins for logic computation in mammalian cells. We create a set of logic circuits (AND, OR, NAND, NOR, and XOR gates) using...
4 sty 2022 · Components of synthetic RNA devices. A major research focus in synthetic biology is the devel-opment of modular frameworks for constructing geneti-cally encoded devices and engineered...
16 wrz 2011 · We will review the rapidly growing field of RNA synthetic biology as it transitions from the molecular design of RNA-based genetic parts and devices to the implementation of these elements in genetic systems for programming complex biological behaviors.
11 mar 2016 · These endeavors highlight the possibility of using synthetic RNA devices as genetically encoded sensors to probe biological transport and intracellular metabolite levels within living cells. In a recent example, protein-responsive synthetic miRNA devices regulating GFP were used to detect endogenous protein levels in mammalian cells.
