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Cutaneous lupus erythematosus treatment algorithm. Treatment of mild or local disease begins with topical therapies, whereas treatment of severe or widespread disease begins with systemic therapies. If the response to therapy is inadequate, arrows indicate the direction of treatment progression.
Class 2–4 topical glucocorticoids are the treatment of choice for cutaneous lupus erythematosus (CLE). A randomized, controlled study has shown that fluocinonide 0.05 % is more effective than hydrocortisone 1 % [ 1 ].
For localized CLE lesions, topical corticosteroids and topical calcineurin inhibitors are first-line treatment. For widespread or severe CLE lesions and (or) cases resistant to topical treatment, systemic treatment including antimalarials and (or) short-term corticosteroids can be added.
30 sie 2010 · Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus erythematosus and urticarial vasculitis in a patient with C2 deficiency
10 cze 2021 · Subacute cutaneous lupus (SCLE) causes skin sores or rashes. It is an autoimmune disorder, meaning it occurs when your immune system attacks itself. Some prescription drugs may increase your risk for SCLE. There is no cure for SCLE. Treatment can help you manage symptoms and avoid SCLE rash flare-ups.
1 wrz 2021 · Drug-induced CLE (DI-CLE) can be classified into two major subtypes, namely, drug-induced SCLE (DI-SCLE) and chronic cutaneous drug-induced lupus erythematosus (CCDILE) [30]. DI-SCLE is the most common subtype, and is more frequently seen in older female patients [ 31 ].
20 gru 2016 · Second- and third-line systemic treatments include methotrexate, retinoids, dapsone and mycophenolate mofetil or mycophenolate acid, respectively. Thalidomide should only be used in selected therapy-refractory CLE patients, preferably in addition to antimalarials.
