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10 maj 2024 · Human immunodeficiency virus type 1 (HIV-1) remains a serious health threat in Indonesia. In particular, the CRF01_AE viruses were the predominant HIV-1 strains in various cities in...
Indonesia is the most epidemic country for HIV in South-East Asia and may largely contribute to the spread of HIV-1 in Asia;1 however, the viral genetic evolution, spatial origins, and...
27 wrz 2019 · To elucidate the epidemiological link between HIV-1B epidemics in Indonesia and those in the remainder of the world, we conducted phylogenetic analyses of HIV-1B strains in Indonesia.
16 mar 2012 · Here, we review recent advances in HIV-1 structural biology, focusing on the molecular mechanisms of viral replication and on the development of new therapeutics. Schematic overview of the...
HIV-1 arose through several independent zoonotic transmissions of simian immunodeficiency viruses during the last century 1–3. Today, HIV-1, along with its less widespread cousin HIV-2, infects over 30 million people worldwide.
The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors.
The entry pathway of HIV-1 and HIV-2 can be divided into three major events: virus binding to the cell, activation and fusion (Figure 4). The viral envelope trimeric complex, composed of the het-erodimer proteins gp120 and gp41, is essential for virus recognition and entry into target cells. Indeed,
