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Although the selective serotonin reuptake inhibi-tors (SSRIs) have better overall safety and toler-ability than older antidepressants, broad-based experience with SSRIs has shown the frequency and type of side effects to be increased relative to clinical trial data.
Sexual side effects are common with most antidepressants. Bupropion and mirtazapine may be least problematic. Many antidepressants are substrates of CYP450 enzymes. See our Cytochrome P450 Drug Interactions chart to help check for interactions. --absent or rare to ++++ relatively common.
1 maj 2023 · Common side effects from SSRIs include sexual dysfunction, sleep disturbances, weight changes, anxiety, dizziness, xerostomia, headache, and gastrointestinal distress. SSRIs also have the potential to prolong the QT interval, which can lead to fatal arrhythmia, torsade de pointes.
Psychiatric side effects of SSRIs have been grouped into the mania spectrum (mania, hypomania, elevated mood), depression spectrum (aggravation of depression, crying, irritability, anger, hypersensitivity),
2 sty 2018 · In our review, nausea was reported in 17 studies; it occurred in 21% of patients, with no difference between SSRIs. The reporting of other side-effects was much more selective. The incidence of agitation was reported in only six out of 16 trials of fluoxetine and nervousness/anxiety in only 10.
If side effects occur, they are most notable during the initial 4 weeks of titrating the dose. Mild & Common Side effects (~10%) Management strategies GI upset (Nausea, diarrhea, pain)
• Any of the common side effects do not go away or gets worse. • You suddenly stop taking your SSRI. Go to the nearest Emergency Department if any of these happen: • You feel like acting on thoughts of harming yourself or others. • You notice early symptoms of serotonin syndrome, low sodium, or bleeding.
