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To test the notion that SSRIs administered immediately before or after surgery were more likely to represent continuation of a home medication than initiation of antidepressant therapy during a hospitalization for surgery, we created 2 additional SSRI variables.
How soon after the operation can the SSRI be restarted will depend on the nature of the procedure and the course of recovery. The length of time off medication increases the risk of symptom recrudescence and relapse of MDD.
1 sty 2022 · Serotonin–norepinephrine reuptake inhibitors as an adjunct to standard perioperative care probably provide small reduction in both acute and chronic postoperative pain and opioid consumption, and small improvement in patient satisfaction without increases in adverse events. The effects of SSRIs are inconclusive because of very limited evidence.
12 lut 2018 · After controlling for sex, age, and type of surgery, presence of prior surgical procedures on the same joint, ASA score, obesity, and the Elixhauser comorbidities, SSRI use was still associated with a reduced risk of revision arthroplasty for any indication (HR, 0.76; 95% CI, 0.61-0.95) and aseptic revisions (HR, 0.72; 95% CI, 0.55-0.93).
29 kwi 2013 · second, defined as administration of the SSRI beginning on the day after surgery (or later), but not before surgery, likely represented an SSRI that was temporarily held prior to...
Selective serotonin re-uptake inhibitors (SSRIs) are the first-line recommended therapy for depressive disorders, however due to their platelet inhibitory actions they have been associated with increased incidences of post-operative bleeding.
Accumulating clinical evidence, supported by biological rationale, supports a statistically significant impact of SSRIs on the risk of bleeding. However the current data do not unequivocally support this to be of clinically importance in the preoperative period.
