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To test the notion that SSRIs administered immediately before or after surgery were more likely to represent continuation of a home medication than initiation of antidepressant therapy during a hospitalization for surgery, we created 2 additional SSRI variables.
The weight of the evidence is that SSRI use increases the risk of bleeding complications during and immediately after surgery. However, given the limited data we cannot estimate the risk for a given patient having a given procedure.
12 lut 2018 · After controlling for sex, age, and type of surgery, presence of prior surgical procedures on the same joint, ASA score, obesity, and the Elixhauser comorbidities, SSRI use was still associated with a reduced risk of revision arthroplasty for any indication (HR, 0.76; 95% CI, 0.61-0.95) and aseptic revisions (HR, 0.72; 95% CI, 0.55-0.93).
In these cases, options include either switching to a different antidepressant or a gradual taper of the SSRI over several weeks before surgery, although this is rarely done in practice . Consensus Recommendation for SSRIs: Take preoperatively, including DOS.
Objective: This study aimed to review the data on the effect of selective serotonin reuptake inhibitors (SSRIs) on bleeding during or after operative procedures and to offer guidelines for clinical management.
Selective serotonin re-uptake inhibitors (SSRIs) are the first-line recommended therapy for depressive disorders, however due to their platelet inhibitory actions they have been associated with increased incidences of post-operative bleeding.
24 cze 2013 · Participants: Five hundred thirty thousand four hundred sixteen patients 18 years or older. Exposure: Perioperative use of SSRIs. Main outcomes and measures: In-hospital mortality, length of stay, readmission at 30 days, bleeding events, transfusions, and incidence of ventricular arrhythmias.
