Search results
28 mar 2024 · Somatic mutations originate in a single cell and are propagated within an individual by DNA replication and cell division 2, 3, 4, 5, 6 (Fig. 1b).
B: Possible outcomes of a neutral mutation in a crypt stem cell: A new mutation that does not alter stem cell fate (yellow) may generate a clone that is outcompeted by wild type cells and lost or replaces other stem cells so the mutant becomes fixed in the crypt as no non-mutant cells remain. Positively selected mutations confer a greater than ...
25 sie 2021 · A subset of somatic cell types have been investigated in depth, and differences between them in clonal structure, mutation rates and processes, and frequency of driver mutations conferring...
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
3 maj 2018 · With single-cell sequencing, somatic mutations can be detected as heterozygous variants that occur in a subset of cells. The ability to detect variants is dependent on uniformity of coverage and allelic balance in genome amplification, as well as on picking cells that contain variants.
3 lip 2021 · We and two Japanese groups have recently shown that cells from the mucosal epithelium of IBD patients frequently carry somatic mutations in PIGR and genes in Toll-like receptor (TLR) and interleukin-17 (IL-17) pathways, most notably NFKBIZ and ZC3H12A .
As opposed to gene-level mutations, mutations that alter longer stretches of DNA (ranging from multiple genes up to entire chromosomes) are called chromosomal mutations. These mutations often...
