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11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to...
17 gru 2021 · From conception to death, human cells accumulate somatic mutations in their genomes. These mutations can contribute to the development of cancer and non-malignant diseases and have also been associated with aging.
1 paź 2021 · Positive selection dominates evolution in somatic tissues. Most somatic mutations are thought to be silent, with minimal phenotypic consequences. However, a small minority of mutations will affect the biology of the cell, either in a way that is selectively neutral or that subjects it to natural selection.
24 gru 2019 · To gain a better understanding of the genome-wide distribution and functional impact of somatic mutations, we leverage the genomic information contained in the transcriptome to uniformly call somatic mutations from over 7500 tissue samples, representing 36 distinct tissues.
Less information is available on somatic mutations in the stomach and small intestine and rectum, but a recent study examined multiple organs by LCM and sequencing in five human donors giving a preliminary view of the mutational landscape of the stomach and small intestine in which stem cells are also arranged into glands (stomach) or crypts ...
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a), similar...
25 sie 2021 · Laser-capture microdissection and mini-bulk exome sequencing are combined to analyse somatic mutations in morphologically normal tissues from nine organs from five donors, revealing variation...
