Search results
Less information is available on somatic mutations in the stomach and small intestine and rectum, but a recent study examined multiple organs by LCM and sequencing in five human donors giving a preliminary view of the mutational landscape of the stomach and small intestine in which stem cells are also arranged into glands (stomach) or crypts ...
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a),...
9 lip 2020 · This approach has generated complete landscapes of somatic mutations from progenitor cells of the small intestine, liver, and colon (Blokzijl et al., 2016), from neuronal stem cells (Bae et al., 2018) and skeletal muscle satellite cells (Franco et al., 2018), and from bronchial epithelial cells (Yoshida et al., 2020), kidney tubular progenitor ...
13 kwi 2022 · Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with the...
9 lip 2020 · Mutations arise in a stochastic fashion in the different cells of a tissue. In contrast to germline mutations, which are copied from the fertilized egg to all somatic cells, postzygotic mutations result in genetic heterogeneity within a tissue or cell population.
25 sie 2021 · Laser-capture microdissection and mini-bulk exome sequencing are combined to analyse somatic mutations in morphologically normal tissues from nine organs from five donors, revealing variation...
6 lip 2022 · Recent advances in sequencing have found somatic mutations in all epithelial tissues studied to date. Here we review how the mutational landscape of normal epithelia is shaped by clonal competition within the stem cell niche combined with environmental exposures.
