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11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked...
17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.
7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
28 mar 2024 · Somatic mutations originate in a single cell and are propagated within an individual by DNA replication and cell division 2, 3, 4, 5, 6 (Fig. 1b).
25 sie 2021 · Most tissues are mosaics of clones originating from single stem cells, and many microscopically visible glandular structures are derived from recent single stem cell ancestors. Mutation rates...
3 lip 2021 · Single-cell sequencing: methods have been developed to call mutations both from single-cell DNA (scDNA) and single-cell RNA (scRNA) datasets . Single-cell technologies have the advantage that mutations can be called even in highly polyclonal tissue, such as postmitotic neurons [ 2 , 3 ].
1 paź 2021 · Mutated cells may reach high frequency in a tissue either through the large-scale expansion of a single clone or through parallel evolution of multiple clones, each carrying a distinct mutation in the same gene or pathway.
