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A somatic mutation is a change in the DNA sequence of a somatic cell of a multicellular organism with dedicated reproductive cells; that is, any mutation that occurs in a cell other than a gamete, germ cell, or gametocyte.
7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.
Somatic mutation, genetic alteration acquired by a cell that can be passed to the progeny of the mutated cell in the course of cell division. Somatic mutations are frequently caused by environmental factors, such as exposure to ultraviolet radiation or to certain chemicals.
Mutations can be grouped into two main categories based on where they occur: somatic mutations and germ-line mutations. Somatic mutations take place in non-reproductive cells.
25 sie 2021 · The human body is composed of somatic and germline cells. Mutations acquired in somatic cells during a lifespan, and their consequences, are restricted to the individual in whom they...
3 lip 2021 · We and two Japanese groups have recently shown that cells from the mucosal epithelium of IBD patients frequently carry somatic mutations in PIGR and genes in Toll-like receptor (TLR) and interleukin-17 (IL-17) pathways, most notably NFKBIZ and ZC3H12A .
