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11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to...
24 gru 2019 · Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.
17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.
3 lip 2021 · Every organ is a micromosaic of cellular clones carrying distinct somatic mutations that compete for space within the tissue but do not always increase cancer risk. Somatic evolution has the potential to affect the disease progress of common complex diseases.
25 wrz 2015 · It is increasingly recognized that somatic mutations underlie a much broader spectrum of human disease beyond cancer. For example, somatic mutations occurring early in development underlie a surprising fraction (6 to 20%) of studied Mendelian disorders .
Somatic mutations can arise during the course of prenatal brain development and cause neurological disease—even when present at low levels of mosaicism, for example—resulting in brain malformations associated with epilepsy and intellectual disability.
7 sty 2022 · Unlike cardiomyocytes, hematopoietic stem cells (HSPCs) are constantly dividing. Somatic mutations in select genes confer a competitive advantage, leading to a clonal proliferation termed CHIP.
