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Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
However, the global market for artificial sweeteners has decreased considerably over the past 10 years due to their possible harmful effects on human health, for example, cancer (Weihrauch and Diehl, 2004), obesity (Yang, 2010), and diabetes (Brown et al., 2010).
Health hazards associated with sodium Cyclamate includes irritation of the skin, eyes, mucous membranes and respiratory tract; diarrhea, photosensitization and birth defects like Down Syndrome and behavioral changes in the offsprings of pregnant women exposed to it.
In a single study, eight persons ingesting sodium cyclamate (70 mg/ kg per day) did not exhibit chromosomal aberrations in their lymphocytes 20. Calcium cyclamate induced chromosomal aberrations in bone-marrow cells of gerbils, but not in bone-marrow cells or spermatogonia of rats, treated in vivo.
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
22 lut 2019 · They sought to determine the effect of various NSSs on the health of adults and kids, including those who were overweight, obese, or at a healthy weight. The effects they studied included: body weight; oral health; blood sugar; eating behavior; cancer risk; cardiovascular disease risk; kidney disease risk; mood and brain function.
