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Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Sodium cyclamate inhibited binding of 125 I-labelled mouse epidermal growth factor to dog kidney, rat hepatoma and rat liver cells, mouse fibroblasts, human foreskin and human skin fibroblasts, human carcinoma and human xeroderma pigmentosum cells in vitro .
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
Many fears have arisen around the associated side effects of consuming artificial sweeteners in addition to broader concerns about their safety for human consumption. The studies previously conducted on saccharin and cyclamate were limited to experimental animals.
Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration. Following its oral administration to two strains of mice, an increased incidence of lymphosarcomas was observed in female mice of one strain; a few bladder tumours were seen in ...
22 maj 2012 · Cancer Risk. Early studies in the 1970s linked the use of artificial sweeteners containing a mix of cyclamate and saccharin to an increased risk of bladder cancer in lab animals. Other early studies showed that bacteria in the intestines may convert cyclamate to cyclohexamine, a carcinogen.
Although there are many causes of hypercalcemia in animals, the most common causes in dogs include paraneoplastic hypercalcemia of malignancy, primary hyperparathyroidism, renal disease, and Addison disease. Please see the table for a list of differential diagnoses.
