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  1. 31 lip 2023 · The highest mortality burden from sickle cell disease was concentrated in sub-Saharan Africa (figure 3C, D), where our cause-specific analysis indicated 29 400 (95% UI 20 300–40 000) people died of sickle cell disease in 2021, an increase of 30·1% (–2·3 to 77·6) since 2000.

  2. 2 lis 2010 · Nature Communications - Sixty years ago it was suggested that the sickle cell disease mutation survives because the heterozygous genotype confers resistance to malaria, resulting in...

  3. In 2021, GBD 1 recorded 75 (55–100) deaths in children under 5 in the UK and 134 (104–172) in France. In fact, it is well documented that childhood mortality due to sickle cell disease is very low in France and the UK.

  4. 23 cze 2022 · A high prevalence has been reported in sub-Saharan Africa, the Mediterranean, the Middle East, and India. With global migration, prevalence is also increasing in other geographic regions, but there are no definitive data on global prevalence and mortality of SCD.

  5. 15 cze 2023 · A Lancet study—the first to estimate the full global mortality burden of Sickle Cell Disease (SCD)—has revealed a strikingly high contribution of SCD to all-cause mortality that is not apparent when each death is assigned to only a single cause.

  6. 1 wrz 2023 · Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this dataset provides a global assessment of sickle cell disease (SCD) birth incidence, prevalence and mortality burden by age and sex for 204 countries and territories from 2000 to 2021.

  7. Findings: Between 2000 and 2021, national incidence rates of sickle cell disease were relatively stable, but total births of babies with sickle cell disease increased globally by 13·7% (95% uncertainty interval 11·1–16·5), to 515 000 (425 000–614 000), primarily due to population growth in the Caribbean and western and central sub ...

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