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28 lis 2023 · Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction. The common laboratory mouse Mus musculus has...
The common laboratory mouse Mus musculus has telomeres that are ~ five times longer than human telomeres, limiting its use for studying telomere biology. In a new study, researchers used a...
3 mar 2020 · Here, we show that telomerase deficient mice with short telomeres (G2-Terc −/−) have an hyper-activated mTOR pathway with increased levels of phosphorylated ribosomal S6 protein in liver ...
24 maj 2018 · Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected.
26 paź 2021 · Recent studies have demonstrated that patients with DC and murine models with critically short telomeres exhibit lower NAD levels, and an imbalance in the NAD metabolome, including elevated CD38 NADase and reduced poly (ADP-ribose) polymerase and SIRT1 activities.
1 wrz 2001 · Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age‐related diseases produced by critical telomere shortening. However, it is not known whether or not short telomeres are irreversibly damaged.
2 mar 2020 · For mice, if a pure, soluble protein antigen is being used and is abundant, a dose of 50-100 µg in adjuvant at each immunization is a sensible general recommendation; for rats and hamsters, a dose of 100-200 µg is sufficient. Lower doses can be used for antigens with higher immunogenicity.
