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17 paź 2019 · Abstract. Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal...
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Chętnie wyświetlilibyśmy opis, ale witryna, którą oglądasz,...
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The common laboratory mouse Mus musculus has telomeres that are ~ five times longer than human telomeres, limiting its use for studying telomere biology. In a new study, researchers used a...
28 lis 2023 · The resulting M. musculus strain, named ‘Telomouse’, had shorter telomeres than those of wild-type M. musculus mice, reaching human length after 15 generations.
24 maj 2018 · Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected.
15 maj 2012 · Telomeres have been linked with aging and disease and, in the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Therapies that impact on telomere length are therefore expected to have an impact on health span. RESULTS:
1 lis 2023 · Compared with mice with long telomere reserve, telomerase knockout mice showed reduced neurogenesis in the dentate gyrus, loss of neurons in the hippocampus and frontal cortex, and related to short-term memory deficits.
26 paź 2021 · Patients with DC have very short telomeres at a young age due to germline mutations of key telomere maintenance genes, and have a high risk for bone marrow failure, cancer, pulmonary fibrosis, liver disease, and numerous other conditions (Dokal, 2011; Savage, 2018; Bhala et al., 2019).
